一、公共生物工程的概念與特征
采用先進(jìn)的計(jì)算機(jī)圖像處理與分析技術(shù)完成白細(xì)胞分類計(jì)數(shù)是輔助診斷血液疾病的重要方法。各種白細(xì)胞間的紋理差異較大,紋理是區(qū)分白細(xì)胞的重要特征之一。局部二進(jìn)制模式(local
binary pattern,LBP)是一種有效的紋理描述算子。本研究提出了一種提取細(xì)胞的改進(jìn)LBP特征用于白細(xì)胞分類識(shí)別的算法。首先,用小波變換對(duì)圖像進(jìn)行分解并重構(gòu),獲得四幅不同頻率的分量圖,對(duì)其中的低頻信號(hào)采用離散余弦變換。此后,用可變大小的子窗口對(duì)變換后的圖像掃描,并根據(jù)不同區(qū)域賦以權(quán)值,獲取改進(jìn)的LBP特征,構(gòu)成加權(quán)直方圖。這種特征既能反映細(xì)胞局部特征又能反映整體特征。根據(jù)測(cè)試樣本和模板的LBP特征直方圖之間的馬氏距離構(gòu)建分類器。根據(jù)這種改進(jìn)LBP特征有效地實(shí)現(xiàn)了白細(xì)胞的5種分類,得到了令人滿意的分類正確率。實(shí)驗(yàn)結(jié)果表明:本研究提出的算法能有效地區(qū)分不同類的白細(xì)胞;與其他一些算法相比,提高了分類的精確度。
Leukocyte Classification Based On an
Enhanced Local Binary Pattern Feature
ZHOU Ying-ying,ZHOU Zhen-yu,SUN Ning,BAO
Xu-dong
。↙aboratory of Image Science and Technology,Southeast
University,Nanjing Jiangsu210096,China;Department
of Biomedical Engineering,Southeast University,Nanjing210096;Department
of Radio Engineering,Southeast University,Nanjing210096)
Abstract:Classification and counting of
leukocyte types,by dint of the advanced computer
technology for image processing and analysis,is of
great importance due to its crucial role in study of
assistant diagnosis of blood diseases.Leukocytes are
different in texture which is one of the important
features in cell classification.Local binary pattern(LBP)is
an efficient operator because of its excellent
capability of description of local texture.Here,a
method based on extracting an enhanced LBP feature,for
identification of leukocytes is introduced.First
discrete wavelet transform(DWT)is adopted to
decomposed images into four kinds of frequency
subimages,and then discrete cosine transform(DCT)to
the low frequency subimages from which the features
are calculated to increase original data.Then the
transformed subimages are scanned with small
changeable windows fromwhich improved features are
obtained and weighted histograms which effectively
express both local and ho-listic features of the
cell areas are constructed according to gray-scale
distributions.Finally,Mahalanobis distance between
corresponding LBP histograms of the test image and
template is used to construct classifiers.With the
enhanced LBP feature extracted by this method,the
satisfying classification accuracy achieves good
effects for dividing leucocytes into five types.The
results of experiments show that the proposed
approach which is discriminative for leukocytes
classification achieves better performance of
leukocytes classification than the others methods.
Key words:Leukocyte classification;Local
binary pattern;Discrete wavelet transform;Discrete
cosine transform;Mahalanobis distance
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